Pentatalaksanaan Bedah Myxofibrosarcoma Punggung Kronis: Sebuah Laporan Kasus Surgical Management of Chronic Myxofibrosarcoma of the Back: A Case Report
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Abstract
Soft tissue sarcoma is a rare malignant tumor that can arise in various parts of the body, including the back. One of its subtypes, myxofibrosarcoma, is known for its relatively slow growth but high risk of local recurrence, making early diagnosis and appropriate management crucial. This case report aims to describe the diagnostic process, surgical management, and functional as well as aesthetic outcomes in a patient with back myxofibrosarcoma.
This study used a descriptive case report design involving a 63-year-old male patient who presented with a back mass that had been developing for approximately 20 years. The observed variables included the clinical characteristics of the mass, anatomical pathology findings, type of surgical intervention, and postoperative condition. The assessment tools consisted of clinical physical examination, histopathological evaluation of tumor tissue, and observation of functional outcomes and the patient’s ability to perform daily activities after surgery.
The examination results revealed a large soft tissue mass with dilated blood vessels on the back. Anatomical pathology confirmed a malignant mesenchymal tumor suggestive of myxofibrosarcoma. The patient underwent wide excision followed by flap reconstruction. Postoperatively, the patient’s general condition was stable without significant complications, the surgical wound improved, and the patient was able to return to normal activities as a construction worker after routine follow-up and care.
This case demonstrates that soft tissue sarcoma of the back, although progressive in appearance and often concerning, can yield good clinical outcomes when managed with adequate surgical intervention according to indications. Patient education regarding the potential success of therapy plays an important role in improving treatment adherence, trust in medical procedures, and optimization of postoperative functional and aesthetic results.
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References
Angervall, L., Kindblom, L., & Merck, C. (1977). Myxofibrosarcoma: a study of 30 cases. Acta Pathologica Microbiologica Scandinavica Section A Pathology, 85(2), 127–140.
Bacon, A., Wong, K., Fernando, M. S., Rous, B., Hill, R. J. W., Collins, S. D., Broggio, J., & Strauss, S. J. (2023). Incidence and survival of soft tissue sarcoma in England between 2013 and 2017, an analysis from the National Cancer Registration and Analysis Service. International Journal of Cancer, 152(9), 1789–1803.
Buscharino, B., SANTOS, A. R. D. O. S., Amato Neto, D. G., Alexandre, M., Yonamine, E. S., & Fucs, P. M. D. M. B. (2023). Soft tissue sarcoma-Santa Casa de São Paulo experience from 2006 to 2019. Acta Ortopédica Brasileira, 31(3), e263799.
Busco, S., Buzzoni, C., Mallone, S., Trama, A., Castaing, M., Bella, F., Amodio, R., Bizzoco, S., Cassetti, T., & Cirilli, C. (2016). Italian Cancer Figures-Report 2015: The burden of rare cancers in Italy= I TUMORI IN ITALIA-RAPPORTO 2015: I tumori rari in Italia. Epidemiologia e Prevenzione, 40(1, suppl. 2), 1–120.
Chen, C., Wang, C., Li, S., Zheng, X., & Yang, Y. (2024). Global, regional, and national burden of soft tissue and extraosseous sarcomas from 1990 to 2021. Preventive Medicine Reports, 47, 102903. https://doi.org/https://doi.org/10.1016/j.pmedr.2024.102903
Cosci, I., Del Fiore, P., Mocellin, S., & Ferlin, A. (2023). Gender differences in soft tissue and bone sarcoma: a narrative review. Cancers, 16(1), 201.
Fletcher, C., Bridge, J. A., Hogendoorn, P. C. W., & Mertens, F. (2013). WHO classification of tumours of soft tissue and bone: WHO classification of tumours, vol. 5. World Health Organization.
Garcia del Muro, X., de Alava, E., Artigas, V., Bague, S., Braña, A., Cubedo, R., Cruz, J., Mulet-Margalef, N., Narvaez, J. A., Martinez Tirado, O., Valverde, C., Verges, R., Viñals, J., & Martin-Broto, J. (2016). Clinical practice guidelines for the diagnosis and treatment of patients with soft tissue sarcoma by the Spanish group for research in sarcomas (GEIS). Cancer Chemotherapy and Pharmacology, 77(1), 133–146. https://doi.org/10.1007/s00280-015-2809-5
García Del Muro, X., Martín, J., Maurel, J., Cubedo, R., Bagué, S., de Álava, E., López Pousa, A., Narváez, J. A., Ortiz, E., Pomés, J., Poveda, A., Pérez Romasanta, L., Tendero, O., & Viñals, J. M. (2011). Guía de práctica clínica en los sarcomas de partes blandas. Medicina Clínica, 136(9), 408.e1-408.e18. https://doi.org/https://doi.org/10.1016/j.medcli.2011.02.004
Gatta, G., Van Der Zwan, J. M., Casali, P. G., Siesling, S., Dei Tos, A. P., Kunkler, I., Otter, R., Licitra, L., Mallone, S., & Tavilla, A. (2011). Rare cancers are not so rare: the rare cancer burden in Europe. European Journal of Cancer, 47(17), 2493–2511.
Hsieh, M.-C., Wu, X.-C., Andrews, P. A., & Chen, V. W. (2013). Racial and ethnic disparities in the incidence and trends of soft tissue sarcoma among adolescents and young adults in the United States, 1995–2008. Journal of Adolescent and Young Adult Oncology, 2(3), 89–94.
Huang, H.-Y., Lal, P., Qin, J., Brennan, M. F., & Antonescu, C. R. (2004). Low-grade myxofibrosarcoma: a clinicopathologic analysis of 49 cases treated at a single institution with simultaneous assessment of the efficacy of 3-tier and 4-tier grading systems. Human Pathology, 35(5), 612–621.
Ifadah, E., Lestari, R. D., Widyantoro, W., Dewi, R., Fauzia, W., Yustika, N. W. A. N., Permatasari, E. D., Nurjanah, U., Ratnaningsih, A., Purwandari, N. P., & Putri, D. S. (2024). Asuhan Keperawatan Medikal Bedah: Teori dan Praktik. PT. Green Pustaka Indonesia.
Johnson, C. J., Pynsent, P. B., & Grimer, R. J. (2001). Clinical features of soft tissue sarcomas. Annals of the Royal College of Surgeons of England, 83(3), 203–205.
Kotilingam, D., Lev, D. C., Lazar, A. J. F., & Pollock, R. E. (2006). Staging soft tissue sarcoma: evolution and change. CA: A Cancer Journal for Clinicians, 56(5), 282–291.
Lestari, R. D. (2023). Bioetika dalam Ilmu Kedokteran dan Multidisiplin Keilmuan. MAHESA: Malahayati Health Student Journal, 3(10), 3218–3224.
Look Hong, N. J., Hornicek, F. J., Raskin, K. A., Yoon, S. S., Szymonifka, J., Yeap, B., Chen, Y.-L., DeLaney, T. F., Nielsen, G. P., & Mullen, J. T. (2013). Prognostic factors and outcomes of patients with myxofibrosarcoma. Annals of Surgical Oncology, 20(1), 80–86.
Mentzel, T., Calonje, E., Wadden, C., Camplejohn, R. S., Beham, A., Smith, M. A., & Fletcher, C. D. M. (1996). Myxofibrosarcoma: clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. The American Journal of Surgical Pathology, 20(4), 391–405.
Mulita, F., Verras, G., Liolis, E., Tchabashvili, L., Kehagias, D., Kaplanis, C., Perdikaris, I., & Kehagias, I. (2021). Recurrent retroperitoneal liposarcoma: A case report and literature review. Clinical Case Reports, 9(9), e04717.
Nakamura, N., Hasebe, S., Yamanaka, S., Fujii, T., Fujibuchi, T., Kitani, T., Takeuchi, K., Sato, Y., Shindo, Y., & Ozaki, T. (2024). Treatments and prognostic factors for bone and soft tissue sarcoma in non-urban areas in Japan. International Journal of Clinical Oncology, 29(3), 345–353.
Sandrucci, S., Trama, A., Quagliuolo, V., & Gronchi, A. (2017). Accreditation for centers of sarcoma surgery. Updates in Surgery, 69(1), 1–7.
Sanfilippo, R., Miceli, R., Grosso, F., Fiore, M., Puma, E., Pennacchioli, E., Barisella, M., Sangalli, C., Mariani, L., & Casali, P. G. (2011). Myxofibrosarcoma: prognostic factors and survival in a series of patients treated at a single institution. Annals of Surgical Oncology, 18(3), 720–725.
Sant, M., Allemani, C., Santaquilani, M., Knijn, A., Marchesi, F., Capocaccia, R., & Group, E. W. (2009). EUROCARE-4. Survival of cancer patients diagnosed in 1995–1999. Results and commentary. European Journal of Cancer, 45(6), 931–991.
Sbaraglia, M., Bellan, E., & Dei Tos, A. P. (2020). The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica, 113(2), 70.
Sharma, J., Deo, S. V. S., Kumar, S., Bhoriwal, S., Kar, M., Barwad, A. W., Thulkar, S., Bakhshi, S., & Sharma, D. N. (2024). Demographic and clinical profile of 1106 adult soft tissue sarcoma patients: A single institutional prospective database experience from India. Asia‐Pacific Journal of Clinical Oncology, 20(3), 386–394.
Stiller, C. (2007). Childhood cancer in Britain: incidence, survival, mortality. OUP Oxford.
Stiller, C A, Trama, A., Serraino, D., Rossi, S., Navarro, C., Chirlaque, M. D., Casali, P. G., & Group, R. W. (2013). Descriptive epidemiology of sarcomas in Europe: report from the RARECARE project. European Journal of Cancer, 49(3), 684–695.
Stiller, Charles A, Botta, L., Brewster, D. H., Ho, V. K. Y., Frezza, A. M., Whelan, J., Casali, P. G., Trama, A., Gatta, G., & Group, E.-5 W. (2018). Survival of adults with cancers of bone or soft tissue in Europe—Report from the EUROCARE-5 study. Cancer Epidemiology, 56, 146–153.
Trama, A., Badalamenti, G., Baldi, G. G., Brunello, A., Caira, M., Drove, N., Marrari, A., Palmerini, E., Vincenzi, B., & Dei Tos, A. P. (2019). Soft tissue sarcoma in Italy: From epidemiological data to clinical networking to improve patient care and outcomes. Cancer Epidemiology, 59, 258–264.